Cerebral Autoregulation of Blood Flow in Hypertension; an MRI study
Research type
Research Study
Full title
Cerebral Autoregulation of Blood Flow in Hypertension; an MRI study
IRAS ID
182640
Contact name
Emma Hart
Contact email
Sponsor organisation
Research and Enterprise Development, University of Bristol
Research summary
The disease processes that drive the development of high blood pressure (hypertension) are incompletely understood. We hypothesise that a reduced brain blood flow might be involved in the development of hypertension, because an increase in blood pressure helps to maintain a constant blood flow to the brain. Narrowing and constriction of vessels causes blood pressure to increase, and our hypothesis is that this may also cause the reaction to changes in blood pressure to be altered. Further, we hypothesise that a consequence is a reduced ability to regulate the blood flow to the brain automatically in response to changes in blood pressure. Thus, we will measure whether there are differences in brain blood flow between subjects with high and normal blood pressures in response to changes in their blood pressure alike those induced by sleep and exercise.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
15/SW/0176
Date of REC Opinion
12 Aug 2015
REC opinion
Further Information Favourable Opinion