Central and peripheral blood pressure in stroke
Research type
Research Study
Full title
Effect of posture and fasting state on central and peripheral blood pressure in patients with stroke
IRAS ID
184563
Contact name
James Faulkner
Contact email
Sponsor organisation
University of Winchester
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Individuals who experience a stroke or transient ischaemic attack (TIA) are at heightened risk of subsequent vascular events, including heart attacks and secondary stroke/TIA. Blood pressure control is considered the most important contributor to positive health outcomes in stroke patients. The measurement of central blood pressure (cSBP) (the blood pressure which is being exerted at the heart), may provide clinicians with important diagnostic and prognostic information over and above that typically obtained from a peripheral blood pressure measure (the blood pressure in the arm). Central blood pressures may be better than traditional peripheral blood pressure measures as: i) peripheral blood pressure may not accurately reflect the effects of peak arterial blood pressure on centrally located organs, ii) central blood pressures may be 50 % superior to peripheral blood pressures when predicting cardiovascular events, and iii) information pertaining to central blood pressures may be more effective in the management of hypertension. While the validity of oscillometric devices which measure central blood pressures has been demonstrated, further study is required to determine precision under normal clinical operating conditions (i.e., reflective of the Hospital/GP practice setting).
As such, this study will assess central and peripheral blood pressures of stroke patients when fasted and non-fasted,and when seated and supine. The study is interested in identifying the effect of the above parameters (fasted vs. unfasted, seated vs. supine) on central and peripheral blood pressures in stroke patients.REC name
South Central - Hampshire A Research Ethics Committee
REC reference
15/SC/0559
Date of REC Opinion
30 Oct 2015
REC opinion
Further Information Favourable Opinion