CCHIRAL version 1

• Research type

  Research Study

• Full title

  Cervical Cancer Hypoxia Imaging Repeatability (CCHIRAL)

• IRAS ID

  213803

• Contact name

  Lucy E Kershaw

• Contact email

  lucy.kershaw@ed.ac.uk

• Sponsor organisation

  The University of Manchester

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Cervical Cancer Hypoxia Imaging Repeatability (CCHIRAL)
  Over 3000 new cases of cervical cancer are diagnosed yearly in the UK. For locally advanced disease (where the cancer has begun to spread outside the cervix), 5-year survival rates are less than 60% and patients report serious treatment side effects. These cancers are treated with chemotherapy and radiotherapy. In some of these cancers there are areas that have very little oxygen available (this is called hypoxia), and in these areas radiotherapy is much less effective. It may be possible to identify these areas using magnetic resonance imaging (MRI) or positron emission tomography (PET), where we inject a small amount of radioactivity that ‘sticks’ to hypoxic parts of the cancer. If these hypoxic areas can be successfully found, the radiotherapy can be increased to those specific parts of the cancer to make sure they are killed, without making the treatment side effects worse.

  The University of Manchester is installing a PET-MRI scanner that combines these two types of imaging in one machine. We think this will be the best way to detect hypoxia in cervical cancers, but we want to test whether it is reliable and make sure we are using the machine in the best possible way. To do this, we would like to scan 15 patients with PET-MRI twice, one week apart, to make sure that the results of the scan are the same.

  This study is funded by the Medical Research Council as part of its Confidence in Concept award to the University of Manchester. Patients with locally advanced cervical cancer will be recruited from the Christie Hospital over the course of one year.

  Study participants will undergo two PET-MRI scans at St Mary's Hospital, (Central Manchester NHS Foundation Trust) separated by one week.

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  17/NW/0591

• Date of REC Opinion

  27 Oct 2017

• REC opinion

  Favourable Opinion