CBT to Reduce Insomnia and Improve Social Recovery in Early Psychosis
Research type
Research Study
Full title
Randomised Study of Web-based CBT Intervention (Sleepio) to Reduce Insomnia and Improve Social Recovery in Early Psychosis (CRISP)
IRAS ID
224101
Contact name
Peter B Jones
Contact email
Sponsor organisation
CPFT
Duration of Study in the UK
2 years, 3 months, 30 days
Research summary
Sleep disturbances and cognitive dysfunction are consistently reported as extremely troublesome aspects of psychotic illnesses. While sleep disturbances are not included in definitions of psychosis they are associated with poor levels of daily function and impaired social recovery. Despite sleep problems being documented as co-occurring with psychosis, sleep remains unexamined as a potential therapeutic target pathway for social recovery. Specific areas of cognition are known to be associated with psychosis, sleep deficits and daily function, yet these have not been tested as possible mediators of the association between improved sleep and better daily function and social recovery. Finally, improved sleep may reduce systemic inflammation that may itself mediate the links between cognition and daily function. This research of inflammatory markers (cytokines) correlated with sleep and cognition will provide pilot data for future immunopsychiatry research.
This study will examine the relationship between sleep quality, daily function and ultimately social recovery in early psychosis. A secondary aim will examine whether specified areas of cognition (i.e. attention, memory, executive function, social and emotional recognition) mediate the proposed association between sleep and social recovery. Participants will have experienced a first episode psychosis and be currently engaged with CAMEO early intervention, in Cambridgeshire and Peterborough NHS Foundation Trust (CPFT). Cameo is a service for people aged 14-65 years old who are experiencing symptoms of psychosis for the first time (http://www.cameo.nhs.uk). A publicly available, online intervention based on cognitive behavioural therapy (CBT) for insomnia (Sleepio) will be utilised to improve sleep. Participants will be randomised to receive the intervention + treatment as usual (TAU) through their CAMEO team or TAU alone over an eight-week period. The entire study will last for seventeen weeks including an eight-week follow-up period.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
19/EE/0352
Date of REC Opinion
11 Dec 2019
REC opinion
Further Information Favourable Opinion