CASK trial - Compression After Surgery of the Knee
Research type
Research Study
Full title
CASK trial, A single-centre, two-arm, controlled, prospective randomized trial comparing standard crepe bandaging with Andoflex TLC Calamine Lite (25-30 mmHg) compression bandaging after knee surgery.
IRAS ID
288969
Contact name
Matt Dawson
Contact email
Sponsor organisation
North Cumbria Integrated Care NHS Foundation Trust
ISRCTN Number
ISRCTN10011099
Clinicaltrials.gov Identifier
RD-CASK-2021, RD-CASK-2021
Duration of Study in the UK
1 years, 4 months, 30 days
Research summary
Medial osteoarthritis – wearing of the inside of the knee joint – can be treated with either knee replacement or osteotomy procedures. With the former, either part or the whole of the knee joint is replaced. With the latter, it involves cutting the tibial and or femoral bone and introducing an opening wedge to change the angle of the knee joint and thereby shift the patient’s weight from the medial to the lateral side (outside) of the knee. For all major knee operations, post-surgery the site of operation can be painful. Increased pain may limit a patient’s progress with post-operative mobilisation. Therefore, research is already ongoing in the field of knee surgery to determine if different type of bandaging of the affected leg post-surgery may improve patient and clinical outcomes. A new method is now available which involves bandaging that compresses the leg. This may reduce pain. This present study aims to assess if compression bandaging is better than standard non-compression bandaging in terms of keeping a patient comfortable by reducing pain and possibly improving other clinical outcomes too. A total of 148 patients will be recruited and allocated to either standard bandaging (74 patients) or Andoflex TLC Calamine Lite compression bandaging (also 74 patients); follow-up of patients will be up to 12 weeks post-surgery. Apart from clinical outcomes such as the degree and type of pain experienced by patients, safety data such as incidence of infection and deep vein thrombosis/pulmonary embolism, plus readmission to hospital will be recorded too. The main objective of the study is whether Andoflex TLC Calamine Lite compression bandaging (worn for 5 days post-surgery) is significantly better than standard bandaging (worn for up to 48 hours post-surgery) at day 5 post-surgery when measured on a visual display pain scale.
REC name
Wales REC 7
REC reference
21/WA/0252
Date of REC Opinion
10 Sep 2021
REC opinion
Further Information Favourable Opinion