Care and Outcomes of Older Persons with Lung Cancer in England and US
Research type
Research Study
Full title
The Care and Outcomes of Older Persons with Lung Cancer in England and US: a comparison from population data
IRAS ID
195904
Contact name
Samuel Janes
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
EE133902-FOPHS-FIHIR, Data Protection Registration Number
Duration of Study in the UK
0 years, 4 months, 31 days
Research summary
Prior work has demonstrated substantial international variation in cancer incidence and mortality, even if the determinants of this differences have not been fully investigated. In particular, efforts to compare health systems’ care and outcomes have been disjointed, owing to challenges collecting data that are representative, population-based, and have sufficient clinical detail. Moreover, understanding the care and outcomes of cancer in older patients is particularly important, as the incidence of cancer increases with age. The presence of others chronic diseases, which also increases with age, can modify the effectiveness of cancer therapy and older patients are frequently excluded from clinical trials, making the generalizability of evidenced-based medical practice tenuous. Given the great interest in understanding and improving the care of the older cancer patients in both the US and England, the proposed project will document differences in survival of lung cancer patients older than 65 years between the two countries. It will also assess the impact of factors such as stage at diagnosis, comorbidity burden, and access to treatment on population-level differences in cancer outcomes. We will compare presentation, treatment, and outcome data from Lung Cancer Dataset (LUCADA)/ National Cancer Intelligence Network’s (NCIN) database of patients in England, and from the US Medicare program, using the Surveillance, Epidemiology, and End Results (SEER) Program -Medicare database. We will include all incident cases, in the corresponding populations, in people older than 65 years during the period 2009-2012.
REC name
London - Chelsea Research Ethics Committee
REC reference
16/LO/0616
Date of REC Opinion
31 Mar 2016
REC opinion
Favourable Opinion