Cardiovascular health in people with Cystic Fibrosis
Research type
Research Study
Full title
Cardiovascular health in people with Cystic Fibrosis
IRAS ID
346467
Contact name
Alex Chan
Contact email
Sponsor organisation
Liverpool Heart and Chest Hospital
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
The Cardiovascular Health in people with Cystic Fibrosis (CVH-CF) study is a research project looking at heart and blood vessel health in adults living with Cystic Fibrosis (CF). Thanks to the new medicines called CFTR modulators, people with CF are now living longer. However, we don’t yet know much about how these treatments or CF itself may affect long-term heart health.
This study will include 32 participants: 16 adults with CF who are taking these newer medicines, and 16 healthy people of similar age and sex for comparison. Everyone taking part must be 18 or older and must not have any history of heart disease or be taking heart-related medicines.
Researchers will collect information at the start of the study and again after 12 months. They will measure things like blood pressure, body weight, and the flexibility of the blood vessels using tests such as pulse wave velocity (PWV) and flow-mediated dilation (FMD). They will also take blood samples to check for markers related to heart and blood vessels' health, such as cholesterol levels, inflammation, and blood sugar control.
The main aim of the study is to find out whether people with CF on these newer therapies have similar or different heart and blood vessel health compared to healthy individuals. The researchers will also monitor whether anyone experiences serious heart problems during the 12 months, such as a heart attack, stroke, or chest pain.
By better understanding how CF and its treatments affect the heart and circulation, this study hopes to support healthier, longer lives for people living with CF. The whole study will take place over two years and could help shape future care and monitoring for this group.REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
26/PR/0641
Date of REC Opinion
3 Jun 2026
REC opinion
Favourable Opinion