Cardiovascular and gut health effects of oat (poly)phenols_v1
Research type
Research Study
Full title
Chronic cardiovascular and gut-bacteria effects of phenolic rich oats in adults with above average blood pressure.
IRAS ID
211656
Contact name
JPE Spencer
Contact email
Sponsor organisation
University of Reading
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 8 months, 17 days
Research summary
It is well known that whole grain products can improve our health and this could, in part, be due to natural elements in whole grains such as phenolic acids. Indeed, regular intakes of phenolic acid related elements found in fruits, vegetables, wine, tea and chocolate have been shown to reduce our risk of suffering from cardiovascular disease. Fiber from whole grains, on the other hand, is an indigestible carbohydrate (that is usually part of plant foods) with many health effects, mainly by feeding the good bacteria in our gut and easing bowel movements. However, the health benefits of phenolic acids from whole grains remain unclear. The main purpose of this study is to test if long term intake of a 2.5 portion of whole grain oats improves your heart, blood vessels and intestinal health; and if phenolic acids are, at least in part, responsible for these effects. Potential health benefits will be measured using a range of non-invasive and harmless tests in Hugh Sinclair Unit of Human Nutrition at University of Reading. We aim to recruit adults, age between 25 and 75 who are non-smoking, generally healthy with high normal to moderately elevated blood pressure. This dietary intervention study will allow development of effective public health advice on the optimum strategy to oat intake and improve gut health, vascular function and cardiovascular disease risk reduction in the UK.
REC name
London - Bromley Research Ethics Committee
REC reference
16/LO/1542
Date of REC Opinion
6 Sep 2016
REC opinion
Further Information Favourable Opinion