Cardiopulmonary outcomes in very prematurely born adults
Research type
Research Study
Full title
United Kingdom Oscillation Study: Cardiopulmonary outcomes in very prematurely born adults
IRAS ID
328154
Contact name
Theodore Dassios
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Follow up of participants from the United Kingdom Oscillation Study (UKOS) has shown us that extreme preterm birth is associated with worse lung function in childhood and adolescence when compared to infants that are born at term. Exposure to corticosteroids on the neonatal unit further reduced lung function.
The participants that were in this original study are now young adults (aged 23-26). The effects of preterm birth on adult health outcomes are not well described. We would like to invite this group back to King’s College Hospital research facilities to undergo a very thorough health assessment in order to investigate the effects of extreme preterm birth on the heart and lung and how they may relate to exercise capacity.
The participants will be invited to London for one day of testing. They will have a detailed assessment of their lung function which will involve a number of breathing assessments where we will measure the flow of breath in and out, the size of breaths and how the air inhaled travels through the lungs.
We will also perform an exercise assessment which involves a six minute shuttle test as well as a period of exercise on a cycle machine called a cycle ergometer. During these tests, we will be recording the heart rate and their breathing rate. A cardiac ultrasound (ECHO) will be performed which will measure lung pressures. Saliva, nasal, sputum and blood samples will be taken for storage and later analysis.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
24/NW/0386
Date of REC Opinion
16 Jan 2025
REC opinion
Favourable Opinion