Cardiac MRI in Prediction of Myocardial Hibernation Recovery - Pilot
Research type
Research Study
Full title
Cardiac MRI in the Prediction of Contractile Recovery Following Revascularisation of Dysfunctional Ischaemic Myocardium - Pilot Study
IRAS ID
143215
Contact name
Sven Plein
Contact email
Sponsor organisation
University of Leeds
Research summary
The pumping function of the heart deteriorates when the blood supply is impaired. This is either due to heart attacks and scarring of the heart, or to the heart ‘hibernating’. Hibernation is an adaptation to poor blood flow which is thought to allow the heart to survive having a poor blood supply. When the heart muscle hibernates the muscle slows down and its pumping function becomes sluggish.
Many patients with weak hearts are considered for operations and procedures which improve the blood supply to the heart. These are done in the hope that the muscle will recover, and that overall pumping function of the heart will improve. Using the tests we have available to us currently we are not always able to tell before the procedure whose heart will improve, and sometimes when we think a heart will improve it does not. This means that some of the sickest patients undergo risky procedures that do not result in any benefit.
By using new Cardiac Magnetic Resonance (CMR) Imaging techniques we think that we might be more able to predict whose heart will recover – this will ensure that the sickest patients get treatment that will benefit them most, and avoid risky treatment in sick patients who will not benefit.
In this study we will ask people who have come for normal heart scans to come back after they have had their treatment to improve the heart’s poor blood supply (either bypass grafts or stenting). Patients will then attend for two further scans, hopefully we will be able to use the information gathered to help us predict recovery, and the time scale of recovery, after treatment in other patients.REC name
North East - York Research Ethics Committee
REC reference
14/NE/0115
Date of REC Opinion
13 May 2014
REC opinion
Favourable Opinion