Cardiac 31P-MRS at 3T
Research type
Research Study
Full title
Cardiac 31-Phosphorous Magnetic Resonance Spectroscopy in Healthy Volunteers at 3T
IRAS ID
242192
Contact name
Christopher Miller
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
31P Magnetic resonance spectroscopy (MRS) is a non-invasive method of assessing cellular metabolism and energy expenditure. It is similar to conventional magnetic resonance imaging (MRI), however instead of using the magnetic field properties of hydrogen containing molecules (such as water), 31P MRS utilises the magnetic field properties of phosphorous-containing molecules. In human cells, stored energy can be released by a reaction that generates a molecule called adenosine triphosphate (ATP), commonly called the ’universal energy currency of the cell’ as it is the principle molecule used to transfer and generate energy in cells. MRS is able to measure quantities of phosphate-containing molecules. \n\nCardiac 31P-MRS is of particular interest, in that disruption and dysfunction to cellular energy processes and reactions are fundamental in the pathophysiology of a number of cardiac disease processes, such as heart failure and ischaemic heart disease. 31P-MRS is able to demonstrate such shifts in cellular energetic reactions, thus allowing further understanding of disease processes and responses to targeted treatments.\n\nThis study aims to perform Cardiac 31P-MRS on a group of healthy volunteers across a range of ages to assess the performance of spectroscopy at Manchester University NHS Foundation Trust, on a 3-Tesla MRI scanner.
REC name
London - Hampstead Research Ethics Committee
REC reference
18/LO/0530
Date of REC Opinion
3 Apr 2018
REC opinion
Further Information Favourable Opinion