Carbohydrate intake and gut hormone release during exercise

• Research type

  Research Study

• Full title

  How does carbohydrate intake alter gut hormone release during exercise?

• IRAS ID

  239073

• Contact name

  Edward Chambers

• Contact email

  e.chambers@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• ISRCTN Number

  ISRCTN12345678

• Clinicaltrials.gov Identifier

  NCT12345678

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Research ‘Summary
  Evidence suggests that acute moderate- to high-intensity exercise suppresses appetite and energy intake in the hours after exercise. There is not typically a compensatory increase in appetite at meals later in the day, highlighting the ability of exercise to induce a negative energy balance and potentially improve weight control. The reduction in acute appetite responses by exercise has been associated with increased release of the gut hormones PYY and GLP-1, which suppress appetite.

  The majority of research investigating the impact of exercise on gut hormone release and appetite responses has been performed in overnight fasted volunteers. In ‘real-life’ situations, many individuals would ingest nutrients during exercise, including sports or energy drinks. These carbohydrate rich solutions would also stimulate the release of PYY and GLP from intestinal L-cells and potentially modulate feeding behaviour. The aim of the study is to therefore investigate the potential additive effects of carbohydrate intake and exercise are on gut hormone release and subjective appetite responses. Healthy volunteers would be asked to complete four experimental visits:
  1. 60-min Rest + Placebo ingestion
  2. 60-min Rest + Carbohydrate ingestion
  3. 60-min Exercise + Placebo ingestion
  4. 60-min Exercise + Carbohydrate ingestion

  Blood samples and subjective appetite responses would be collected through the 2 hour experimental visits. An ad libitum meal would be served at the end of each visit to quantify changes in energy intake.

  Summary of Results
  Carbohydrate and exercise independently influence key appetite-regulating hormones.

  Temporal changes in postexercise appetite are linked to acetate, lactate and peptide YY.

  Postexercise energy intake is associated with glucagon-like peptide 1 and succinate levels.

• REC name

  South West - Frenchay Research Ethics Committee

• REC reference

  19/SW/0007

• Date of REC Opinion

  24 Jan 2019

• REC opinion

  Further Information Favourable Opinion