Capability 2
Research type
Research Study
Full title
A 3 and 5 year review of the CAPAbility project to compare Patient–reported Outcomes of Performance, Functional Ability and Quality of Life after insertion of the Journey II Bi-Cruciate Stabilised Knee System with the Genesis II prosthesis
IRAS ID
290436
Contact name
Iain McNamara
Contact email
Sponsor organisation
Norfolk and Norwich University Hospitals NHS Foundation Trust
Duration of Study in the UK
5 years, 1 months, days
Research summary
The original study (CAPAbility) was designed to look at whether a newer type of knee replacement joint (Journey BCS) which was designed to provide improved kinematic (motion of joint) outcomes improve patient’s experiences following total knee replacement(TKR) surgery. The original CAPAbility study successful recruited and the results are being analysed at the moment.
This is the proposal for the 3 and 5 year follow up study to look at patient outcomes in the longer term as part of best practice for a trial on prostheses, especially one that involves a newer prosthesis.
Osteoarthritis of the knee is a common musculoskeletal condition which is expected to significantly increase during
the next two decades as the incidence of obesity and ageing rises. Total Knee replacement is undertaken for this
condition in patients who do not respond to other treatments. Evidence suggests that up to 34% of patients have poor
outcomes following their knee replacement which put patients at risk of not being able to exercise or undertake
physical activity. This can mean that they are more prone to conditions such as diabetes and cardiovascular disease.
This is important to patients and also puts a significant burden on the NHS.This is the longer terms follow up of a trial that was designed to compare patient reported, clinical, kinematic and radiological outcomes for two different types of knee replacement joint.
REC name
London - Harrow Research Ethics Committee
REC reference
21/LO/0220
Date of REC Opinion
27 Apr 2021
REC opinion
Further Information Favourable Opinion