Cancer Tissue Bank V3

• Research type

  Research Tissue Bank

• IRAS ID

  351022

• Research summary

  Cancer Tissue Bank

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  24/LO/0847

• Date of REC Opinion

  20 Nov 2024

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Cancer Tissue Bank (CTB) aims to collect samples of blood, urine, saliva from patients with suspected cancer. Furthermore, tumour and normal tissue, from those patients undergoing an operation to remove tissue from different types of benign condtions will be asked to donate tissue. Donation to the CTB will not alter the
  treatment of the patient in any way. Samples will be collected at Barts NHS Healthcare Trust and CTB tissue collection centres. Prospective donors will be given an information sheet
  explaining samples/data collected and type of research to be carried out on samples collected and there right to
  consent or to withdraw samples any time. Consent will be obtained by Clinicians, Research Nurses or designated
  trained professionals during routine hospital clinics.
  The CTB is licensed by the Human Tissue Authority (licence 12199) to store human tissue for research and has
  ethics approval from the Research Ethics Committee (Renewal pending) to collect and store and distribute samples
  for cancer related research.

• Research programme

  A wide range of clinical, basic and translational research programs will be undertaken by scientists and doctors and their teams (clinical and non-clinical academics and undergraduates/ post graduate students). The aim is to develop new diagnostic and therapeutic tests for various types cancer and other diseases. This will include examination of anonymised patient data alongside pathological and molecular / biochemical analysis of tissues, urine, blood, saliva, normal and diseased tissues. A range of modern molecular pathological and laboratory techniques will be employed. These include state of the art analysis for changes in DNA, RNA, proteins and cell types. The aim would be to generate new diagnostic tests for patients as well as aid in therapy development. Cell lines will be developed from tissues to enable greater understanding of different cell types in distinct diseases. The data generated from these research programs will include, but not restricted to gene expression profiles, biomarker profiles and image etc. Understanding of the basic molecular mechanisms in normal and diseased tissue will lead us to develop new treatments for cancer patients.

• Storage license

  12199

• RTBTitle

  Cancer Tissue Bank

• Establishment organisation

  Queen Mary University of London

• Establishment organisation address

  Barts Cancer Institute, Centre for Tumour Biology

  John Vane Science Centre, Charterhouse Square

  London

  EC1M 6BQ