Cancer Tissue Bank @ Barts Health V1

• Research type

  Research Tissue Bank

• IRAS ID

  145512

• Research summary

  Cancer Tissue Bank @ Barts Health V1

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  14/LO/2031

• Date of REC Opinion

  4 Dec 2014

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  The CTB@BH aims to collect samples of blood, urine, saliva from patients with cancer. Furthermore, tumour and normal tissue, from those patients undergoing an operation to remove tissue from different types of cancer will be done. Donation to the CTB@BH will not alter the treatment of the patient in any way. These samples and any data collected will be stored at local hospital as well as the Barts Cancer Institute. Patients will be given an information sheet explaining samples/data collected and type of research to be carried out on tissue collected and there right to consent or to withdraw tissue any time. Consent will be obtained by Clinicians, Research Nurses or designated trained professionals during routine clinics. CTB@BH will be developed exclusively for collaborative research to improve the standard of cancer research in the UK for the benefit of cancer patients. The CTB@BH is licensed by the Human Tissue Authority (licence 12199) to store human tissue for research. and has ethics approval from the Research Ethics Committee (Application being prepared) to collect and store and issue tissue samples for cancer related research.

• Research programme

  A wide range of basic and translational research programs will be undertaken by scientists and clinical and non-clinical academics and undergraduates/ post graduate students. This will include pathological and molecular / biochemical analysis of tissues, urine, blood, saliva, normal and diseased tissues. A range of modern molecular pathological and laboratory techniques will be employed including immunohistochemistry advanced microscopic and digital imaging , in situ hybridisation, laser microdissection, quantitative real-time PCR, gene expression microarrays, mRNA expression profiling, in vitro primary cell culture, analysis of DNA, RNA and proteins using a range of methods. The data generated from these research programs will include gene expression profiles, biomarker profiles and image etc. Understanding of the basic molecular mechanisms in normal and diseased tissue will lead us to develop new treatments for cancer patients.

• Storage license

  12199

• RTBTitle

  Cancer Tissue Bank @ Barts Health V1

• Establishment organisation

  Queen Mary University of London

• Establishment organisation address

  Centre for Tumour Biology

  Charterhouse Square

  London

  EC1M 6BQ