Cancer MitomiRs
Research type
Research Study
Full title
Mitochondrial microRNA and the mitochondrial proteome in cancer
IRAS ID
249367
Contact name
Nigel D Heaton
Contact email
Sponsor organisation
Kings College Hospital
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Dysregulation of energy generation and usage is a cardinal characteristic of cancer. The main site of energy production in the cell is in mitochondria. Mitochondria have a well defined set of proteins that dictate their function. This set of proteins is known is known as the mitochondrial proteome, most of which is encoded in the nuclear DNA but some components are encoded in the mitochondrial DNA that is found within mitochondria themselves. Throughout the body compartments there are small fragments of circulating nucleic acids called microRNA and these microRNA can modulate gene expression to alter the protein composition of a cell. A small subset of microRNA have been isolated from mitochondria and are known as mitochondrial microRNA. The aim of this work is to look at how the mitochondrial proteome and mitochondrial microRNA change as a cancer progresses.
REC name
London - Brent Research Ethics Committee
REC reference
18/LO/1831
Date of REC Opinion
21 Jan 2019
REC opinion
Further Information Favourable Opinion