CAN-BE intervention feasibility study (Version 1.0)
Research type
Research Study
Full title
A feasibility study to test an intervention to change adherence to inhaled antibiotics in patients with bronchiectasis
IRAS ID
196331
Contact name
Carmel Hughes
Contact email
Sponsor organisation
Queen's University Belfast
ISRCTN Number
ISRCTN21712871
Duration of Study in the UK
0 years, 6 months, 28 days
Research summary
Non-cystic fibrosis (CF) bronchiectasis is a chronic lung condition in which patients present with irreversible dilation of one or more of their airways. Patients commonly experience cough, chronic phlegm (sputum) production and repeated infection. Pseudomonas aeruginosa is a bacterium (bug) which is found in the phlegm of up to 30% of non-CF bronchiectasis patients. These patients require more antibiotics, are admitted to hospital more and attend more clinic appointments that patients without this bug. Colistimethate sodium and tobramycin are effective inhaled antibiotics used to treat P. aeruginosa infection, yet patients continue to have repeated infections requiring further antibiotics. This may be because patients do not take their inhaled antibiotics as they have been prescribed (non-adherence). Research conducted at QUB found that among patients who were prescribed inhaled antibiotics for P. aeruginosa infection, 53% were found to be adherent to inhaled antibiotics. Adherence to inhaled antibiotics was also found to be independently associated with having fewer infections (adherent patients had 2.6 pulmonary exacerbations per year compared with non-adherent patients). \n\nAn intervention to change adherence to inhaled antibiotics has been developed in line with the Medical Research Council’s guidance for developing and evaluating complex interventions and uses a novel approach to behaviour change. \n\nThis feasibility study will test if the intervention can be delivered as intended to patients with bronchiectasis and whether, or not, patients consider it to be an acceptable and useful form of support for adherence. \n\nThe intervention will be delivered to five participants recruited from the Regional Respiratory Centre at the BHSCT. A researcher will use a manual and supporting materials to deliver the intervention to each participant over a series of three study visits. Feedback will be sought from participants about the acceptability and usability of the intervention. Data regarding the study design and implementation will also be collected.\n\n
REC name
HSC REC A
REC reference
16/NI/0031
Date of REC Opinion
4 Mar 2016
REC opinion
Further Information Favourable Opinion