Cadaveric Testing of a Novel Total Shoulder Replacement (TSR)
Research type
Research Study
Full title
Cadaveric testing of a novel Total Shoulder Replacement (TSR) to assess the kinematics and the implant-bone mechanical fixation
IRAS ID
132972
Contact name
Hamidreza Alidousti
Contact email
Sponsor organisation
Imperial College London Clinical Research Office
Research summary
Total shoulder arthroplasty (TSA) is an effective therapy for many painful shoulder conditions. Despite promising short-term results, loosening remains a particular issue of concern in the artificial shoulder in long-term . A novel TSR that seeks to improve surgical procedure for implantation, kinematics and fixation performance and thus improve longevity will be designed in our research group. The new design will be investigated through established computational and experimental methods to evaluate functional outcome.
The cadaver trial is part of a proof of concept study and prototypes developed from the initial design and computational stages. Designed components will be implanted in the glenoid and humeral head of the cadaveric joints. The kinematics, as well as the relative motion between the implant and bone to determine fixation quality, will then be measured to assess the performance of the new designs. The feasibility of implantation of the components by a new surgical approach will also be assessed on cadaveric specimens. The prototypes shall be considered successful if the components are accurately placed in the joint and if they can recreate the natural kinematics of the joint and a fixation that can safely withstand physical loading condition with minimal interfacial motion.
REC name
London - Fulham Research Ethics Committee
REC reference
13/LO/1839
Date of REC Opinion
19 Nov 2013
REC opinion
Favourable Opinion