Burden of RSV Disease in Children
Research type
Research Study
Full title
REspiratory Syncytial virus Consortium in EUrope (RESCEU) study: Defining the burden of disease of Respiratory Syncytial Virus in Europe.
IRAS ID
224486
Contact name
Steve Cunningham
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
4 years, 5 months, 31 days
Research summary
The REspiratory Syncytial virus Consortium in EUrope (RESCEU) is wishes to understand the burden of disease caused by human respiratory syncytial virus (RSV) infection. RSV is a common virus that can cause severe respiratory disease in individuals at the extremes of the age spectrum and in high risk groups. New vaccines and therapeutics against RSV are in development and will soon be available on the European market – so understanding who might benefit from these is crucial.
The study in this application is part of one of 6 workstreams for the whole project. The study wishes to find out how often RSV affects otherwise healthy infants born at term, and whether RSV disease in those infants leads to later recurrent wheeze (and possibly asthma). The University of Edinburgh and NHS Lothian (ACCORD) are sponsoring the Edinburgh portion of this workstream, with data from all sites later being pooled. To understand this aim, this observational study will recruit healthy infants born at term from birth until the age of 3 years (maximum): This includes two cohorts: A passive birth cohort (n=9,000 total, n=1800 Edinburgh) and an active birth cohort (n=1,000, n=200 Edinburgh). All participants will have a nasal swab at birth and also a questionnaire shortly after birth and one year, then yearly questionnaires until age 3 if they needed admission to hospital with a respiratory infection.
The active birth cohort in addition have blood, nose, stool and urine samples around the fifth day of life together with a mouth swab. In the active group, parents are asked to contact the research team in the first year of life if infants have a respiratory infection, to have further nose swab (looking for RSV) and parents questionnaires.REC name
South East Scotland REC 01
REC reference
17/SS/0086
Date of REC Opinion
11 Aug 2017
REC opinion
Further Information Favourable Opinion