BRITROC-2
Research type
Research Study
Full title
BriTROC-2: Longitudinal sample collection to investigate adaptation and evolution of ovarian high grade serous carcinoma
IRAS ID
270543
Contact name
Iain McNeish
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
BriTROC-2 is a sample collection study from women with ovarian cancer from the point of diagnosis to the time of disease relapse.
Ovarian cancer has a poor prognosis. The large majority of patients with ovarian cancer will relapse and ultimately develop fatal chemotherapy resistance. Although there is a wealth of information regarding the molecular basis of ovarian cancer at diagnosis, very little is known about the drivers of treatment resistance (both intrinsic and acquired) and the processes that are active at relapse. This research requires sequential collection of tumour material for women throughout the course of their disease.
This multicentre study will collect tumour samples, ascites (fluid within the abdomen) and blood from women with newly diagnosed ovarian cancer and follow these women through to relapse of their disease. The samples collected will be used to look at patterns within the tumour to identify those that are able to predict response to chemotherapy and outcome. Assays and models will be developed that can look at the process that are active in a tumour at time of sample acquisition. This will give clues into the mechanisms that drive treatment resistance. Ultimately this research aims to guide future treatment options for women with ovarian cancer.
Recruitment will be over 3 years and this study will be conducted at sites with expertise in manging ovarian cancer and the ability to carry out the appropriate sample collection and collect high quality clinical data.
This study is the second collaborative project within the UK to collect samples from women with ovarian cancer. The success of the first study, BriTROC-1, demonstrated the feasibility of sample collection from women with relapsed ovarian cancer. The methods and frameworks established in BriTROC-1 will be used for BriTROC-2.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
20/EE/0181
Date of REC Opinion
28 Sep 2020
REC opinion
Further Information Favourable Opinion