BristolHumanNeuronalPhysiology v1.0
Research type
Research Study
Full title
Neurophysiology underlying enhanced computational capability of human neurons
IRAS ID
310984
Contact name
MIchael Ashby
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The human brain has unique capabilities, but we do not understand what underlies this enhanced function. There are already some documented differences in the structure and function of human neurons compared to those of other animals, but studies have been limited by access to intact human brain tissue. In this study, we aim to study the synaptic and circuit properties of human neurons in live tissue removed during already-scheduled brain surgeries. We will only use tissue that is removed as part of the clinical procedure and that is not needed for post-surgical clinical testing. Specifically, using this tissue, we will uncover the mechanisms that endow human synapses and neural circuits with enhanced computational capabilities using electrophysiological, imaging-based and genetic characterisation of human neurons.
REC name
London - Central Research Ethics Committee
REC reference
22/PR/0763
Date of REC Opinion
16 Jun 2022
REC opinion
Favourable Opinion