BrIaRS

• Research type

  Research Study

• Full title

  Brain Injury and Repair Samples (BrIaRS)

• IRAS ID

  318294

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust & University of Cambridge

• Duration of Study in the UK

  9 years, 10 months, 31 days

• Research summary

  Immunological disorders of the central nervous system (CNS) are a diverse group of conditions in which the immune system causes tissue damage to the CNS. Many of these conditions remain poorly understood and can have limited treatment options.

  To be able to develop new ways to diagnose these disorders and identify treatments, we need to understand the mechanisms of the tissue damage and if/how repair can happen. We can use samples (such as blood or cerebrospinal fluid (CSF)) coupled with clinical data (such as clinical assessments or imaging) to gain this understanding.

  In this study, we propose to use samples (and data, where possible) which are collected by one of the following routes:
  • as part of another ethically-approved study, where the participant (including patients and healthy controls) has given consent for their samples/data to be used in other studies
  • during a clinical procedure for diagnosis or treatment, where the patient has given consent to donate surplus tissue for research purposes
  • during post-mortem, where the patient’s representative has given consent to donate surplus tissue for research purposes

  No new samples will be collected as part of this study.

  The samples will then be stored and analysed, and information from the analysis can be coupled with clinical data where consent has been given to also use this.

• REC name

  Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

• REC reference

  22/YH/0237

• Date of REC Opinion

  19 Oct 2022

• REC opinion

  Favourable Opinion