Brains for Dementia Research (BDR 3) Blood Sub-Study

• Research type

  Research Tissue Bank

• IRAS ID

  254208

• Research summary

  Blood BioBank for the Brains for Dementia Research cohort

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  19/SC/0114

• Date of REC Opinion

  30 Jul 2019

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Blood (tissue and fluids) will be collected by venepuncture from participants already part of Brains for Dementia research, to yield the following formats: plasma, serum, cells, DNA, RNA. The selection of sample types is to allow maximum use by dementia researchers. Samples will be collected at 5 BDR centres but will be stored in a central repository at King's College London.

  The collection of blood samples is desirable, but an optional extra within Brains for Dementia Research. Written consent will be obtained from adults with capacity and the advice of a consultee sought in the cases where capacity is lacking. The only additional data to be collected will be technical and related to sample collection and this will be linked to the BDR dataset. The unique aspect of this biobank relates to the ability to link antemortem blood collection with ongoing clinical data collection through BDR Brain Bank and eventual post-mortem pathology quantification.

• Research programme

  The BDR Blood Biobank is in addition to the established BDR project which aims to relate standardised clinical assessment during life with data obtained at post-mortem brain donation. This will enable studies requiring many hundreds of samples and increase the ability to correlate clinical presentation and psychometric assessment with the neuropathological findings at death. BDR will be a resource not only for participating tissue banks but the wider neurodegeneration research community, including Europe and beyond, academic and commercial institutions. Disease specific study groups are run for neuroscientists and neuropathologists from other institutions to further increase awareness in the scientific community of the facility, and promote dementia research. The tissue will be used for research on neurodegenerative diseases allied to dementia. There are five main categories of research (i) clinico-apthological (ii) molecular pathology (iii) molecular genetic (iv) biochemical (v) transcriptional analysis. The addition of samples from the BDR Blood Biobank will enable discovery and validation of biomarkers. The overall aim of the project is to facilitate research to find new treatments and a cure for dementia.

• Storage license

  12293

• RTBTitle

  Blood BioBank for the Brains for Dementia Research cohort

• Establishment organisation

  King's College London

• Establishment organisation address

  London Neurodegenerative Diseases Brain Bank, Box PO65

  Institute of Psychiatry, Psychology and Neuroscience

  London

  SE5 8AF