Brain Tissue Donation for Research

• Research type

  Research Tissue Bank

• IRAS ID

  265212

• Research summary

  The Manchester Brain Bank

• REC name

  North East - Newcastle & North Tyneside 1 Research Ethics Committee

• REC reference

  19/NE/0242

• Date of REC Opinion

  25 Oct 2019

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Tissues stored within the Manchester Brain Bank are located within the Clinical Sciences Building at Salford Royal Hospital with some archived tissue to be stored at the A.V. Hill Building at the University of Manchester premises on Oxford Road. These include:- Fixed, paraffin embedded and frozen brain and spinal cord tissue and in some cases small samples of other tissues and CSF, are collected at autopsy with full informed consent from:

  - clinically well-characterised donors suffering from a range of dementias, neurodegenerative and vascular disorders
  and occasionally related psychiatric or genetic disorders largely via prospective clinical studies within the Cerebral
  Function Unit but also via national initiatives such as Brains for Dementia Research.

  - volunteer normal control donors largely with clinical assessment during life

  - clinically well-characterised donors who suffer from neurological conditions such as stroke, epilepsy, traumatic brain injury and brain tumours

  - blood samples of patients with dementia that have been or are under the care of the Salford Cerebral Function Unit.
  This latter collection is covered by a separate ethics (reference 05/Q1405/24)

• Research programme

  The Manchester Brain Bank is an open access tissue bank supplying tissue for projects into the functioning of the brain and nervous system. Potential donors with brain disorders and normal controls are recruited mainly through clinical research programmes. Samples are supplied for work including molecular and biochemical studies and genetics. Diseases studied will include dementias,cerebrovascular disease, neurodegenerative diseases, some psychiatric disorders, stroke, epilepsy, traumatic brain injury and some brain tumours. Samples are provided to any applicants who can demonstrate that their project is scientifically and ethically valid.

• Storage license

  12172

• RTBTitle

  The Manchester Brain Bank

• Establishment organisation

  University of Manchester

• Establishment organisation address

  Oxford Road

  Manchester

  M13 9PL