Brain signatures of resilience and staying well
Research type
Research Study
Full title
Does brain activity predict relapse and remission at five year follow-up?
IRAS ID
142500
Contact name
Liam Mason
Contact email
Sponsor organisation
King's College London
Research summary
There is a high degree of relapse in schizophrenia and other disorders involving psychosis. Talking therapies, such as cognitive-behavioural therapy for psychosis (CBT-p), have shown promising results in terms of reducing relapse and promoting remission. We previously examined the brain changes following a treatment of CBT-p in a sample of patients with a diagnosis of schizophrenia (REC reference 209/02). This study showed that CBT-p produces both structural and functional brain changes in areas associated with emotion, cognition and motivation. We would now like to examine whether these brain changes are associated with reduced relapse over the past five years since that study was completed. This will give us some important clues as to which brain changes are important for maintaining a high level of functioning and well-being, as well as providing targets for newly developed therapies.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
14/LO/0325
Date of REC Opinion
17 Apr 2014
REC opinion
Further Information Favourable Opinion