BOOST
Research type
Research Study
Full title
Biological Correlates of outcomes from Stem Cell Transplant
IRAS ID
133007
Contact name
Paul AH Moss
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
3 years, 4 months, 30 days
Research summary
Stem cell transplantation (SCT) can be effective in curing patients of leukaemia and lymphoma. Following allogeneic stem cell transplantation, the immune system of the donor replaces that of the patient. There are several problems that can occur following allogeneic stem cell transplantation. One of the main complications that arises after transplant is graft-versus-host-disease (GvHD)- a condition in which the donor immune system recognises the patient's normal cells as 'foreign' and attacks them leading to organ damage. Other complications after transplant can include graft rejection and immunodeficiency (resulting in increased susceptibility to infections). The donor immune system is also thought to have a 'graft-versus-leukaemia (GvL)' effect whereby residual leukaemia or lymphoma is eradicated by the new donor immune system. We would like to prospectively collect tissue samples from patients who undergo SCT to further study the biology of these issues and advance our understanding of the way in which SCT works.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
15/WM/0194
Date of REC Opinion
3 Aug 2015
REC opinion
Further Information Favourable Opinion