Bone microarchitecture in paediatric Crohn's disease
Research type
Research Study
Full title
Mr. ABC Study: MRI Assessment of Bone microarchitecture in paediatric Crohn's disease
IRAS ID
244027
Contact name
Jarod Wong
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
2 years, 4 months, 1 days
Research summary
Children and adolescents with Crohn’s disease are at increased risk of suboptimal bone and muscle development. Crohn’s disease has a direct effect on bone health, which can cause thinner or weaker bones. Around half of total bone mass is accrued during puberty, however children with Crohn’s disease often have delayed onset of puberty, meaning that their bones may be unable to develop properly. This may in turn lead these people to have increased lifetime risk of fractures. It is important to understand the effects of Crohn’s disease on bone health by carrying out detailed assessments of bone in this population. Current methods of assessing bone health using dual x-ray absorptiometry (DXA) scans do not provide sufficient information on the detailed structure of bones, and are therefore not acceptable methods of assessing the fragility of bones or their risk of fracturing. The developmental endocrinology research group in Glasgow has a record of accomplishment in developing innovative methods of evaluating bone health. We believe that MRI scans represent an excellent way of investigating the detailed structure of bone. Novel MRI techniques have been used to assess the bone health of children and adults with various chronic diseases. The aim of this study is to use these novel methods of MRI to assess the bone and muscle health of children and adolescents with Crohn’s disease.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
18/YH/0229
Date of REC Opinion
6 Jun 2018
REC opinion
Favourable Opinion