Bone microArchitecture in Crohn disease (BACk study) version 1
Research type
Research Study
Full title
Bone Microarchitecture In Adults With Childhood Onset Crohn's Disease
IRAS ID
204464
Contact name
Jarod Sze Choong Wong
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Children with crohn’s disease are at risk of poor bone health as a result of the disease itself and treatment with steroid medicines. This may continue to be a problem in adulthood, although there is little information on adult bone outcome of these individuals. Current methods of detecting osteoporosis such as dual energy absorptiometry (DXA) scans do not provide information on the detailed structure of bones and do not identify those at risk of sustaining fractures. In Glasgow, we have a track record of looking at innovative methods of assessment of bone health and believe that MRI scans represent an excellent way of assessing this detailed structure of bone akin to a virtual bone biopsy. We have been performing these studies in adults and children with different types of chronic disease. The aim of this study is to assess bone health using MRI of the lower limb in adults with childhood onset crohn's disease in comparison with a group of healthy age matched adults. This has never been performed previously and will help us understand the underlying bone abnormalities in adults with crohn’s disease. This will provide us with a platform to launch future follow-up studies.
REC name
North of Scotland Research Ethics Committee 2
REC reference
16/NS/0060
Date of REC Opinion
10 Jun 2016
REC opinion
Further Information Favourable Opinion