Body Composition and Lipid Metabolism at Rest and During Exercise
Research type
Research Study
Full title
Body Composition and Lipid Metabolism at Rest and During Exercise: A Cross-Sectional and Prospective Analysis
IRAS ID
233173
Contact name
Oliver Chrzanowski-Smith
Contact email
Clinicaltrials.gov Identifier
Duration of Study in the UK
6 years, 6 months, 26 days
Research summary
Impaired fat use at rest has been associated with obesity and insulin resistance (Kelley et al., 1999). However, there is currently insufficient evidence on these relationships to inform public health guidelines. There is a specific lack of evidence in a large diverse range of adults, to provide generalisability, exploring:\n\n1) Whether fat use during exercise is altered in individuals with obesity\n2) Whether fat use at rest and during exercise is associated with prospective changes in body composition\n3) The amount fat use at rest and during exercise varies on a day-to-day basis (i.e. the intra-individual variability)\n4) Physiological, metabolic, lifestyle and genetic characteristics that are associated with fat use at rest and during exercise \n\nTherefore, the objectives of this study are:\n\n1) To explore whether fat use is associated with body composition and prospective changes in body composition \n2) To explore associations between fat use and physiological, metabolic, lifestyle and genetic variables\n3) To assess the intra-individual variability of fat use. \n\nThis study is an observational cross-sectional and prospective study. A wide range of adults classed as either ‘healthy’ or ‘at-risk of metabolic disease’ will be recruited. \n\nParticipants will visit the Human Physiology laboratories at the University of Bath on four occasions. Visit 1 is for screening and study familiarisation. Visits 2, 3 and 4 are to be completed within 7-35 days. Visits 2 and 3 are identical, involving lifestyle monitoring (dietary and physical activity), a one-off urine and blood sample, and assessment of fuel use at rest and during exercise (the latter through a maximal incremental graded cycling exercise test). Visit 4 involves body composition analysis via a dual-energy x-ray absorptiometry (DEXA) scan in addition to optional skeletal muscle and / or fat tissue biopsy. Participants will also be offered an optional 6-month follow-up session (Visit 5) involving body composition analysis (DEXA scan).
REC name
South West - Central Bristol Research Ethics Committee
REC reference
17/SW/0269
Date of REC Opinion
5 Dec 2017
REC opinion
Further Information Favourable Opinion