Blood/urine markers for Drug Discovery for Renal Disease in diabetes
Research type
Research Study
Full title
Blood/urine markers for Drug Discovery for Renal Disease in diabetes (DDRD study).
IRAS ID
187029
Contact name
Luigi Gnudi
Contact email
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Diabetic nephropathy (kidney problems caused by diabetes) is a devastating chronic vascular complication of diabetes. New treatments are urgently needed for preventing or slowing down the progression of diabetic kidney disease.
Samples of serum/plasma/urine will be obtained from patients with diabetes and different degree of renal impairment.
In this project cells in culture will be treated with plasma or serum or urine; cells extracts or supernatant will be studied to screen for modulation (activation/inhibition) of different cellular pathways using gene array, metabolomic and/or proteomic. Once some cellular pathways have been identified specific analysis will be conducted on the biological material collected to confirm specific "cell signatures" that could represent potential target for treatment.Recruitment and identification of diabetic patients with different degree of renal risk will be conducted within Guy’s and St Thomas NHS Foundation Trust. We currently have an electronic database with all the information of diabetic patients who will be selected to participate in this study.
REC name
South East Scotland REC 02
REC reference
15/SS/0144
Date of REC Opinion
15 Sep 2015
REC opinion
Further Information Favourable Opinion