Blood Pressure in children and young adults with ADPKD
Research type
Research Study
Full title
Optimal Blood Pressure level in Children and Young People with Autosomal Dominant Polycystic Kidney Disease
IRAS ID
179568
Contact name
Paul Winyard
Contact email
Sponsor organisation
UCL Great Ormond Street Institute of Child Health
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited condition affecting the kidneys; it results in cysts forming in the kidneys. We know that adults with ADPKD often have high blood pressure (BP). High BP can result in health problems such as heart attack or stroke. There is very little research looking at children and young people with ADPKD, but some research has shown that high BP may start in childhood and that children can show different signs of high BP such as strain on their heart.
This is a study to investigate BP in children and young people with ADPKD and will be taking place in a number of large hospitals in the UK. During this study we aim to measure BP using different methods, this will include measuring it over 24 hours using a portable device at home. We will also assess the health of the heart and blood vessels by looking at a more accurate type of BP measurement called central BP using a new external monitoring device. We will also collect urine and blood samples at the same time as normal clinic tests, and these will be stored for later investigations and research to help us diagnose and treat ADPKD.
The aim of this research is to help us better understand BP in children and young people with ADPKD and to compare it to BP in children and young people who do not have ADPKD. This will be the largest study ever done to look at BP in such detail in this group of children and young people with ADPKD. If we find that high BP is a problem in this group of patients, we may be in a better position to treat children and young people with ADPKD.
REC name
London - Hampstead Research Ethics Committee
REC reference
15/LO/1100
Date of REC Opinion
17 Jul 2015
REC opinion
Further Information Favourable Opinion