Blood immunophenotyping in staging of indolent B-cell lymphomas V1.0
Research type
Research Study
Full title
Evaluation of peripheral blood (PB) immunophenotyping in the detection of bone marrow involvement in cases of follicular lymphoma (FL), mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL).
IRAS ID
171701
Contact name
Sunil Iyengar
Contact email
Sponsor organisation
The Royal Marsden NHS Foundation Trust
Duration of Study in the UK
3 years, 3 months, 1 days
Research summary
This study will determine whether peripheral blood flow cytometry can reduce or replace invasive bone marrow examinations in patients with slow growing lymphomas.
Patients with certain types of slow growing (indolent) lymphomas, including the most common sub-type, follicular lymphoma, require a bone marrow examination for staging of their lymphoma. This provides prognostic information and can be important for planning treatment. However, despite the use of local anaesthetic, and in some cases sedation, bone marrow examinations can cause pain and discomfort to patients. Complications are rare but include risk of bleeding, infection and even nerve damage.
Flow cytometry of peripheral blood samples can detect low levels of circulating lymphoma cells. A previous study has demonstrated that detection of lymphoma cells by peripheral blood flow cytometry has a good correlation with bone marrow involvement. This study will seek to find if this correlation is evident in a larger, statistically significant patient cohort. Depending on the study results, invasive and painful bone marrow procedures could potentially be reduced or eliminated in patients with certain slow growing lymphomas.
Patients diagnosed with follicular lymphoma, mantle cell lymphoma or marginal zone lymphoma and being treated at the Royal Marsden NHS Foundation Trust will be eligible for this study. Participation in the study will require one peripheral blood sample to be taken before the patient's routine bone marrow biopsy. The study is expected to last between 2 - 3 years for data collection of 108 samples.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
16/SC/0644
Date of REC Opinion
22 May 2017
REC opinion
Further Information Favourable Opinion