Blood cells in cardiovascular conditions v1
Research type
Research Study
Full title
Investigating circulating blood cell phenotype in cardiovascular conditions
IRAS ID
246886
Contact name
Daniel Bromage
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Cardiovascular conditions, including acute myocardial infarction and myocarditis, are a common cause of mortality. Inflammation is implicated in most cardiovascular conditions and is necessary to activate reparative mechanisms; however, there is compelling evidence implicating dysregulated inflammation in the pathophysiology of many such conditions. Myeloid cell subsets are thought to be especially important in regulating inflammation and the synergy of pro- and anti-inflammatory myeloid cells appears critical. If anti-inflammatory devices are pathologically overwhelmed, inflammation can escape temporal and spatial control, and contribute to many features characteristic of the failing heart.
Pre-clinical studies have suggested that modulating circulating cell phenotype can mitigate adverse outcomes and several promising targets have been identified. In this study, circulating cells will be isolated from whole blood samples and studied for their expression of cell surface and intracellular molecules, and function. Understanding these circulating cells in cardiovascular conditions may allow for the development of new medicines that will modulate their function and lead to improved outcomes for these patients.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
19/SC/0362
Date of REC Opinion
10 Jul 2019
REC opinion
Favourable Opinion