BLISS
Research type
Research Database
IRAS ID
343775
Contact name
David Cairns
Contact email
Research summary
Blood cancer clinical trials Long term follow-up using Integrated health SystemS data (BLISS)
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
25/EE/0099
Date of REC Opinion
1 Jul 2025
REC opinion
Further Information Favourable Opinion
Data collection arrangements
BLISS is a research database which include approximately 5500 multiple myeloma patients recruited into ten practice changing multiple myeloma clinical trials conducted at the University of Leeds Clinical Trails Unit between 2008 and 2021. These studies are now closed to further follow-up, therefore further outcomes will be obtained via linkage to healthcare systems data held and processed by NHS England. Linkage to NHS England data will include mortality data, cancer registrations and treatment (systemic anti-cancer therapy and radiotherapy) and Hospital Episode Statistics.
Research programme
The purpose of the database is to provide linked clinical trial and healthcare systems data that will be used to evaluate the quality and accuracy of HSD (including deaths, cancer registrations, treatment and hospital admissions) for use in determining clinical trial endpoints. We will undertake further clinical, scientific and methodological research including comparing the predictive ability of frailty indices (supporting the design of future trials); investigating diversity and representativeness of trial participants, and related outcomes; understanding myeloma bone disease treatment and outcomes; and evaluating the reported time to next line treatment as a surrogate for progression-free survival.
Research database title
Blood cancer clinical trials Long term follow-up using Integrated health SystemS data (BLISS)
Establishment organisation
University of Leeds
Establishment organisation address
Governance and Compliance Directorate
Leeds
LS2 9JT