Bladder changes in different OAB patients and the impact of treatment

• Research type

  Research Study

• Full title

  An investigation into bladder and urine changes in overactive bladder patients of differing severity and duration and the impact of treatment.

• IRAS ID

  203037

• Contact name

  Arun Sahai

• Contact email

  arun.sahai@gstt.nhs.uk

• Sponsor organisation

  Nottingham University Hospitals NHS Trust

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  Overactive Bladder (OAB) affects 1 in 8 people with prevalence increasing with age. It causes symptoms of urinary urgency, day and night time urinary frequency, and incontinence, and seriously reduces the quality of life. Although the condition is so common much about it is still unclear, particularly longer term changes, which, with an aging population are becoming an increasing concern. This study, part funded by Allergan, therefore aims to look at how the condition changes with time and how different treatments affect it with the hope of improving the long term management.
  Any OAB patients over 18 and able to give informed consent who are referred to the Urology Centre at Guy’s hospital are eligible to take part. They will be assigned to one of four groups depending upon the length of their OAB diagnosis (<1 yr, 1-5yrs, 5-10yrs,>10yrs). All patients recruited will be asked to give us access to the quality of life questionnaires and bladder diaries that form part of their normal routine care. We would also ask them to provide a urine sample on each visit to the clinic. Additionally, patients who require a cystoscopy as part of their normal care, will be asked if we can take four small biopsies at the same time as this cystoscopy so that we can look at the properties of their bladder wall. They will also be asked to return for a second, additional set of biopsies 4-8 weeks later, so that we can see if the treatment has affected the bladder wall. We aim to recruit 20 patients per group undergoing cystoscopy to provide biopsies and urine samples and an additional 20 per group receiving oral medication or other treatment without cystoscopy to provide just urine samples. This study is anticipated to take about 18-24 months for recruitment and analysis.

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  16/LO/1306

• Date of REC Opinion

  9 Aug 2016

• REC opinion

  Favourable Opinion