Biomedical Informatics for post-transplant recurrent GMN
Research type
Research Study
Full title
Clinical improvements in Renal Transplantation using Biomedical Informatics: Focus on Recurrent glomerulonephritis (GMN)
IRAS ID
183961
Contact name
Paramit Chowdhury
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Trust
Duration of Study in the UK
2 years, 5 months, 31 days
Research summary
This study is part of the NIHR Health Informatics Collaborative (NIHR HIC) that brings together five of the country's leading NHS Trusts with large NIHR Biomedical Research Centres to make NHS clinical data more available to researchers, industry and the NHS community. One of the five scientific themes is kidney transplantation.
An important problem for kidney grafts is the re-appearance of the same disease that caused the transplant to happen in the first place. Recurrent disease is seen in 4 - 20% (1 - 4 in 10) of patients that receive a kidney transplant.
In this study we will identify the frequency of recurrent disease and the epidemiological and clinical factors that are associated with recurrence.
Secondly, we will use previously collected laboratory data (including genetic data) to assess the risk recurrence and severity of it.
The four centres involved in the transplant theme are some of the largest kidney transplant centres in the United Kingdom, performing around one third of all kidney transplants in the United Kingdom. We decided to focus on recurrent disease in order to optimise the benefits of the present collaboration. The number of patients that we can incorporate will allow us to answer questions that could not have been answered in a single centre approach.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
15/EM/0449
Date of REC Opinion
28 Sep 2015
REC opinion
Favourable Opinion