Biomechanical properties of keratoconic eyes
Research type
Research Study
Full title
Biomechanical properties of the keratoconic eye pre and post collagen crosslinking
IRAS ID
171228
Contact name
Hetal Buckhurst
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
In keratoconus (KC) corneal thinning and protrusion can cause myopia and irregular astigmatism, affecting vision. The biomechanical properties of the cornea is maintained by an intricate collagen network, which is responsible for its shape and function. In KC this collagen network is disrupted resulting in the cornea losing its shape and function. Keratoconic changes are focal and localised to certain regions of the cornea and the early detection of these changes is challenging. Screening methods include corneal topography (evaluation of anterior corneal surface curvature), tomography (assessing the morphological features of the anterior segment) and aberrometry (measuring the optical aberrations of the eye). More recent research suggests that the biomechanical destabilization of the cornea may precede topographic and tomographic evidence of KC. Management of KC depends on disease severity with severe cases being treated with keratoplasty and less severe cases with corneal-collagen-crosslinking (CXL). CXL is an emerging technique, which aims to increase the biomechanical strength of the keratoconic cornea. Despite strong evidence of changes in the biomechanical properties in human corneas following CXL, there is a significant need for accurate measures of biomechanical changes in vivo pre and post CXL. Until recently technical limitations have restricted the ability to assess the biomechanical properties of the whole cornea in vivo. With the introduction of the CorvisST (Oculus) it is now possible to assess regional biomechanical behaviour of the cornea. The output from the device provides a variety of parameters to indicate the cornea’s biomechanical strength.
To date, the association between the deflection behaviours in various regions of the cornea in keratoconic eyes pre-and post CXL has not been studied. In order to effectively assess the clinical benefits of CXL such information is vital. The primary goal of this investigation is to investigate regional biomechanical properties of the keratoconic eye before and after CXL.REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
15/WM/0107
Date of REC Opinion
14 Apr 2015
REC opinion
Further Information Favourable Opinion