Biomarkers & Prediction of Response in Psychological Therapy V1
Research type
Research Study
Full title
Biomarkers and Prediction of Response in Psychological Therapy (BioPoRT)- A Feasibility Study
IRAS ID
174741
Contact name
Thalia C Eley
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
The overall objective of this project is to identify genetic and psychosocial predictors of treatment response in patients with depression or anxiety receiving psychological treatment via the “Improving Access to Psychological Therapies” (IAPT) initiative. The study has two phases. In Phase A we will use already collected de-identified data to explore predictors of treatment response in a large sample of patients seen within the South London and the Maudsley NHS Foundation Trust (SLaM) IAPT service. SLaM currently use an electronic patient record system which holds anonymised clinical data. Researchers are permitted to request access to this data via the Trust’s guardian and the oversight committee. We have been granted approval by the SLaM NHS Trust/BRC for Mental Health Clinical Record Interactive Search (CRIS) oversight committee to analyse deidentified data from all patients within SLaM seen within the IAPT services since their outset. We are not requesting permission from this ethics committee for approval of this process but have outlined it for your information. In Phase B we will recruit participants interested in providing more information beginning with Southwark, proceeding as follows:
1. Screening. Potential participants will be contacted with a letter requesting consent to contact for research.
2. Contacting. On return of consent to be contacted patients will be contacted and provided with further information about the study and asked to complete several questionnaires.
3. Saliva sample collection. Once questionnaires have been completed participants who have consented to provide a saliva sample will be sent a kit to do so by post.
4. Clinical information on those that have taken part will be obtained from electronic records from the IAPT service and combined with the data provided by the patients.
Phase A. Our first aim is to use already collected de-identified clinical record data (Phase A) to explore clinical and demographic predictors of psychological treatment response in a large population based sample. Using Phase B data, our second aim is to estimate the heritability of response to a psychological treatment. Our third aim is to create a combined clinical/demographic and genetic risk index that predicts response to psychological treatments. Our fourth aim is to explore predictors of relapse following psychological treatments.
The study is also a feasibility study in readiness for a larger study of similar design across a number of different IAPT services.REC name
South Central - Oxford C Research Ethics Committee
REC reference
15/SC/0586
Date of REC Opinion
19 Nov 2015
REC opinion
Further Information Favourable Opinion