Biomarkers of knee osteoarthritis progression: VIDEO trial

• Research type

  Research Study

• Full title

  Potential novel biomarkers of knee osteoarthritis progression: subanalysis of the VIDEO study.

• IRAS ID

  230754

• Contact name

  Nigel Arden

• Sponsor organisation

  Royal National Orthopaedic Hospital,

• Duration of Study in the UK

  14 years, 10 months, 30 days

• Research summary

  Knee osteoarthritis is a common disease affecting up to 45% of adults during their lifetime. There are currently no treatment strategies in place which are able to delay the progression of early arthritis to severe and painful joint disease. There is growing evidence that some blood and urine based tests might be helpful in predicting who is at high risk of progressing to early joint failure. This research will aim to identify individuals at high risk of progressing into more advanced and painful knee arthritis by analysing a spectrum of blood, genetic and urine markers associated with tissue degeneration and joint inflammation. This could lead to better stratification of the individuals at risk for future interventions but also help to identify potential pathological pathways as future targets for interventions.

• REC name

  London - Queen Square Research Ethics Committee

• REC reference

  17/LO/1654

• Date of REC Opinion

  2 Oct 2017

• REC opinion

  Further Information Favourable Opinion