Biomarkers Linked to Coronary Artery Disease in Diabetic People
Research type
Research Study
Full title
Biomarkers and Models of Vascular Functions Linked to Coronary Artery Disease in Diabetic and Nondiabetic People
IRAS ID
354727
Contact name
Rasha Al-Lamee
Contact email
Sponsor organisation
Joint Research Compliance Office, Imperial College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This research seeks to learn more about the impact of diabetes on the health of blood vessels by examining cells that derive the regeneration of blood vessels. This will be done through the study of peripheral blood mononuclear cells , investigating 2 sources: endothelial progenitor cells, and stem cells that are reprogrammed form blood cells (induced pluripotent stem cells (iPSCs). The activity of these cells is typically compromised in individuals with diabetes. These cells will be used to model diabetes in the lab, and also to develop a diagnostic tool to identify patients who are at greater risk of coronary artery disease (CAD) worsening.
Two populations of patients, namely those with CAD and diabetes, and those with CAD but not diabetes, will participate in the study. In addition, the study will also compare results with normal volunteers. Blood will be taken from the participants at Hammersmith Hospital, and the scientists will study the genetic and functional characteristics of the isolated blood cells. The study will also explore whether it would be possible to create vascular disease in the laboratory by using reprogrammed cells from blood samples to create stem cells.
By learning more about these cells, researchers also hope to be able to improve how they predict early on which patients are most at risk and perhaps find new treatments for slowing or halting the development of CAD in individuals with diabetes. The study is being supported by Imperial College London and will last for two years.REC name
London - Surrey Borders Research Ethics Committee
REC reference
25/LO/0309
Date of REC Opinion
3 Jun 2025
REC opinion
Further Information Favourable Opinion