Biomarkers in liver failure, Version 1.0 June 2016
Research type
Research Study
Full title
Identification of outcome biomarkers in patients with liver failure.
IRAS ID
210046
Contact name
Kenneth Simpson
Contact email
Duration of Study in the UK
10 years, 0 months, 3 days
Research summary
Acute liver injury (ALI) and acute liver failure (ALF) are rare clinical conditions, the latter often associated with a poor outcome. To improve outcomes for these patients, we need to develop a clearer understanding of the pathophysiology of this condition. Biomarkers and novel imaging techniques are vital to investigating and understanding the pathophysiology of ALI. Patients with ALI or ALF aged over 16 and due to any cause will be eligible to take part in the study. The study will involve collection of biological samples (blood, urine, stool and breath) from included patients once daily for up to 7 days. For patients undergoing liver transplantation, a small sample of explanted (removed) liver tissue will be obtained. A small subgroup of patients with paracetamol induced acute liver failure will be eligible to be included in a pilot MRI (magnetic resonance imaging) study, which will involve two MRI scans during the first 7 days of their admission. All patients will be recruited from the Royal Infirmary of Edinburgh.
REC name
Scotland A REC
REC reference
16/SS/0136
Date of REC Opinion
2 Sep 2016
REC opinion
Favourable Opinion