Biomarker response to cardiac ischaemia
Research type
Research Study
Full title
Study of biomarker response to stress-induced ischaemia in patients with ischaemic heart disease
IRAS ID
274219
Contact name
Robert Storey
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 5 months, 31 days
Research summary
Research Summary
This study will assess the impact of deficiency of blood supply (ischaemia) induced by exercise stress testing using a treadmill on levels of a substance in the blood called glycosylated apolipoprotein (ApoJ-Glyc) in 25 patients with angina and narrowing of arteries that supply the heart with blood (obstructive coronary artery disease, CAD) compared with 15 control patients with non-cardiac chest pain and no CAD. CAD patients must be at least 18 years old, have symptoms of angina related to exertion or stress, be able to walk unaided on a treadmill and have >70% narrowing of a major artery supplying the heart muscle. Control patients will be matched with CAD patients for age and sex. Blood levels of ApoJ-Glyc will be assessed over 6 hours after exercise. It is hoped that ApoJ-Glyc levels will prove useful in helping to diagnose cardiac ischaemia in patients without acute myocardial infarction (heart attack), as current tests can be slow and expensive with imperfect sensitivity and specificity. The study is funded by GlyCardial Diagnostics and will be undertaken in the Clinical Research Facility (CRF) and Cardiology Department at the Northern General Hospital. This will be the only site involved. Patients will be recruited over a 12-month period, without treatment differing from the norm i.e. a single-centre, prospective cohort observational study. Patients will be prepared and observed as per usual protocol for treadmill tests and also have an intravenous cannula inserted for blood sampling purposes. Following treadmill testing, patients will be transferred by wheelchair to the CRF for ongoing blood sampling up to 6 hours after exercise. The electronic database will be accessed and maintained via computers held securely within the Cardiovascular Research Unit (CVRU).Summary of Results
25 patients with symptoms of heart artery disease and 15 control patients who did not have heart artery disease completed the exercise treadmill test with collection of blood samples before and up to 6 hours after exercise. The blood samples were analysed for the novel biomarker as well as a traditional heart marker called troponin. The biomarker levels tended to be lower in the patients with heart artery disease before exercise but did not change significantly after exercise. Blood troponin levels increased with exercise and appeared to be a good marker of significant heart artery disease.REC name
West of Scotland REC 4
REC reference
20/WS/0005
Date of REC Opinion
15 Jan 2020
REC opinion
Favourable Opinion