Biomarker expression and response to Chemo-radiotherapy in NSCLC
Research type
Research Study
Full title
Determination of Biomarker Expression for Correlation with Response to treatment with Concurrent Chemo-radiotherapy in Patients with Inoperable Locally advanced Non-Small Cell Lung Cancer (NSCLC): a Feasibility Study
IRAS ID
83518
Contact name
Abhro Chaudhuri
Contact email
Sponsor organisation
United Lincolnshire Hospital NHS Trust
Research summary
This study aims to look at the pre-existing samples of lung tissue. This tissue is routinely taken from patients with inoperable locally advanced Non-Small Cell Lung Cancer, whom have undergone treatment with a concurrent courses of chemotherapy and radiotherapy.
ERCC1, RRM1 and BRCA1 all have roles in the repair mechanisms of damaged DNA. In addition expression levels of these proteins may effect the patient’s response to certain types of chemotherapy. Hence, the aim of the study is to measure the expression levels of these proteins in diagnostic samples routinely taken from patients and to compare the results to the patients outcome. This research will then give a better understanding as to whether there is a link between the expression of these proteins and response to certain treatments.Therefore the study aims are to determine whether the level of response to concurrent chemoRadiotherapy has an association with the expression of this gene in patients with Non Small Cell Lung Cancer.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
13/EM/0125
Date of REC Opinion
31 May 2013
REC opinion
Further Information Favourable Opinion