Biological link between Anxiety and Outcomes Post Knee arthroplasty
Research type
Research Study
Full title
Investigating the biological link between mental health status and outcomes following Total Knee and Hip Replacement
IRAS ID
359311
Contact name
Amr Selim
Contact email
Sponsor organisation
Robert Jones and Agnes Hunt Orthopaedic Hospital
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, especially the knees and hips. Over 98,000 people undergo primary total knee replacement, and 99,000 undergo primary total hip replacement each year in the UK. However, up to 10-20% of people who have a knee replacement are unhappy with the results, which is much higher than for hip replacements (5-7%). The soft tissue that lines inside the hip and knee joint is different with the knee joint having significantly more lining than the hip, and this lining tissue is known to contribute to inflammation in the joint, which also links to pain/dysfunction.
Emerging evidence suggests that psychological factors, such as anxiety and depression, are associated with dissatisfaction following Knee and hip replacement.
This project will explore how factors such as the degree of inflammation in the joint's soft tissue lining and mental health, including depression/anxiety, are related, and how they in turn could be related to how people feel after surgery. We will collect data from people undergoing knee and hip replacements through surveys, blood tests and biological samples obtained during surgery from the joint lining. Understanding these factors could help improve treatment in the future and provide better outcomes for patients.REC name
South Central - Oxford C Research Ethics Committee
REC reference
25/SC/0330
Date of REC Opinion
20 Nov 2025
REC opinion
Further Information Favourable Opinion