Bioimpedance monitoring in diabetic ketoacidosis V3

• Research type

  Research Study

• Full title

  Bio-impedance monitoring in diabetic ketoacidosis feasibility study

• IRAS ID

  168958

• Contact name

  Julian Hamilton-Shield

• Contact email

  j.p.h.shield@bristol.ac.uk

• Sponsor organisation

  University Hospitals Bristol NHS Foundation Trust

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  The aim of this studyis to test the feasibility of real time measurement of intracellular fluid (ICF) and extracellular fluid
  (ECF) via bioimpedence to reduce the risk of cerebral oedema (a rare but very serious complication) in children
  presenting with Diabetic Ketoacidosis (DKA). The study will recruit in children aged 216
  presenting with DKA in
  Bristol Royal Hospital for Children and the study will use a Maltron BioScan 920II
  Segmental Abdominal Body
  Composition Analyser to measure Bioelectrical
  Impedance. The study will define changes in ECF and ICF during
  standard insulin and fluid treatment bioimpedance
  and compare to controls.If successful, a future trial (Randomised
  Control Trial) will investigate whether using bioimpedance
  to control changes in ECF:ICF by modulating intravenous
  (IV) fluid therapy in response to bioimpedance
  measurements will reduce the risk of cerebral oedema in children
  presenting with DKA.

• REC name

  South West - Central Bristol Research Ethics Committee

• REC reference

  15/SW/0083

• Date of REC Opinion

  8 Jun 2015

• REC opinion

  Further Information Favourable Opinion