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BIOCRYPT - Version 1

  • Research type

    Research Study

  • Full title

    Determination of relative bioavailability, bioconversion and bioefficacy of β-cryptoxanthin in comparison to β-carotene from biofortified maize and external stable isotopes using compartmental modelling

  • IRAS ID

    270816

  • Contact name

    Georg Lietz

  • Contact email

    georg.lietz@ncl.ac.uk

  • Sponsor organisation

    HarvestPlus

  • Clinicaltrials.gov Identifier

    NCT04153968

  • Duration of Study in the UK

    0 years, 11 months, 31 days

  • Research summary

    Since no quantitative information currently exists on how effectively the pro-vitamin A carotenoid β-cryptoxanthin is converted to vitamin A in humans, this proof of principle study aims to compare the efficacy of both β-cryptoxanthin and β-carotene to yield vitamin A from biofortified maize. This data is critical before the breeding strategy for biofortified maize is directed towards high β-cryptoxanthin-containing varieties in order to reduce vitamin A deficiency in low- and middle-income countries.

  • REC name

    North West - Greater Manchester East Research Ethics Committee

  • REC reference

    22/NW/0046

  • Date of REC Opinion

    20 Apr 2022

  • REC opinion

    Further Information Favourable Opinion