Biochemical and biomechanical investigation of aortic tissue
Research type
Research Study
Full title
Biochemical and biomechanical investigation of aortic tissue
IRAS ID
333745
Contact name
Jillian Madine
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Thoracic aortic aneurysm/aortic dissection (TAAD) manifests a devastating clinical course if undiagnosed and untreated. The major mortality and morbidity associated with TAAD lies with acute dissection or rupture; both of these are very difficult to predict. This project brings together inter-disciplinary expertise covering biomechanics, biochemistry and mathematical modelling to better understand the role of tissue mechanics, extracellular matrix factors, amyloid deposition, inflammation and clinical characteristics in TAAD. The project aims to:
- Further our understanding of the inflammatory mechanisms contributing to TAAD with acute aortic dissection or rupture.
- Develop a mathematical model which can help better predict disease manifestation.
- Develop a biomarker detection tool which can be used in a clinical setting to diagnose disease using patient blood samples.
- Develop a point-of-care testing technique that can assist in predicting post-operative prognosis.
- Characterise biomechanical and biochemical properties of aortic tissue, and comparison with synthetic graft materials and diseased tissue.REC name
Wales REC 7
REC reference
25/WA/0094
Date of REC Opinion
14 Mar 2025
REC opinion
Favourable Opinion