Bioavailability of dietary antioxidants in volunteers
Research type
Research Study
Full title
Bioavailability and physiological effects of dietary antioxidants of different functional foods and beverages in volunteers.
IRAS ID
178769
Contact name
Ivan Petyaev
Contact email
Sponsor organisation
Lycotec Ltd
ISRCTN Number
ISRCTN89815519
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
It is now well established that consumption of specific foods and food ingredients can be associated with considerable health benefits. The potential effect of targeted nutritional interventions can be enormous in managing such major public health problems as obesity, diabetes, cardiovascular disease and cancer. Nevertheless, it is clear that appropriately designed functional foods need to be developed first.
The planned study primarily addresses questions related to the bioavailability of health-promoting food components, where bioavailability is defined as the ease with which nutrients are freed from the food and absorbed from the digestive tract to be incorporated into the human body. This research project will evaluate nutrikinetics and comparative bioavailability of a range of dietary supplements comprising carotenoids, resveratrol, flavanols, omega 3 fatty acids etc as well as their combinations at different doses in different food matrices, such as chocolate, butter and vegetable oils. Quantitative parameters will be assessed in the postprandial period following daily oral dose administration (with main meal) and/or following daily administration for different periods of time (4 and 8 weeks) in healthy adult subjects (volunteers).
Only healthy volunteers will take part in the planned study. The selected functional foods will be added to their normal diet in limited amounts, practically excluding any possibility of adverse effects. Blood sample collection for evaluating nutrikinetics/bioavailability of dietary supplements will be the only minimally invasive procedure used in this study. Non-invasively collected samples of exfoliated corneocytes and sebaceous gland secretions from the surface of facial skin as well as cerumen (ear-wax) and tear fluid samples will also be used for assessing physiological effects of the dietary supplements.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
15/EE/0150
Date of REC Opinion
6 May 2015
REC opinion
Unfavourable Opinion