Bioavailability of beetroot compounds in older adults, 0.1

• Research type

  Research Study

• Full title

  Bioavailability of phenolic compounds, betalain and inorganic nitrate following incremental portions of whole beetroot in older and younger adults.

• IRAS ID

  202902

• Contact name

  Daniel West

• Contact email

  daniel.west@newcastle.ac.uk

• Sponsor organisation

  The Newcastle upon Tyne Hospitals NHS Foundation Trust

• Duration of Study in the UK

  0 years, 8 months, 30 days

• Research summary

  Aims: The aim of this randomised, crossover trial is to compare the bioavailability of phenolic compounds, betalain and inorganic nitrate after the ingestion of three incremental portions of whole beetroot in healthy younger and older adults.
  Study design and protocol: We will recruit 15 healthy, young adults (age 18-35 years) and 15 healthy, older adults (age 60-75 years). Eligible subjects will be allocated in random order to four interventions (100g beetroot, 200g beetroot, 300g beetroot, dose of inorganic nitrate as a positive control). The duration of each intervention will be five hours. The washout period between each phase will be one week. For the purpose of randomisation a Latin-Square approach will be utilised. The primary outcome of the study is to assess the difference in bioavailability of nitrate, phenolic compounds and betalains between younger and older subjects. Secondary outcomes are changes in blood pressure, blood flow, and tolerability to the interventions.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  16/EE/0376

• Date of REC Opinion

  26 Sep 2016

• REC opinion

  Further Information Favourable Opinion