BEAST V1.0
Research type
Research Study
Full title
Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST).
IRAS ID
221878
Contact name
Pankaj Sharma
Contact email
Sponsor organisation
Ashford and St Peter's Hospitals NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Cerebral venous thrombosis (CVT) is a rare cerebrovascular condition that accounts for less than 1% of all strokes. The overall annual incidence is estimated at 1.32 per 100000 person-years. CVT commonly affects young adults and is more prevalent in women, accounting for approximately 75% of the adult affected patients and may lead to mortality or severe morbidity.
BEAST is the largest epidemiological and genetic study on CVT conducted worldwide including 8 European countries, several centres in the USA and one research centre in Mexico.
BEAST will contribute to improve the understanding of the pathophysiological mechanisms underlying this uncommon form of stroke that affects mostly young women. The research may lead to identifying groups at risk, providing advice on prognosis and potentially facilitating the identification of specific therapeutic targets.Lay summary of study results:
To better understand the genetic basis of cerebral venous thrombosis (CVT), a rare cause of stroke, we established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) to recruit highly selected cases initially of European descent and later from other populations. Once recruited, the consortium undertook a genetic analysis and identified a gene for this condition. This may help us to understand the mechanisms of CVT and ultimately predict its occurrence and provide a treatment.REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
17/NE/0145
Date of REC Opinion
10 May 2017
REC opinion
Favourable Opinion